Mefv (GeneName), Pyrin (ProteinName), MEFV_RAT.
Rat Mefv/ Pyrin ELISA Kit
Natural and recombinant rat Pyrin
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homotrimer. Interacts (via the B box-type zinc finger) with PSTPIP1. Interacts (via the B30.2/SPRY domain) with several components of the inflammasome complex, including CASP1 p20 and p10 subunits, CASP5, PYCARD, NLRP1, NLRP2 AND NLRP3, as well as with unprocessed IL1B; this interaction may lead to autophagic degradation of these proteins. Interacts with NFKBIA and RELA. Interacts weakly with VASP and ACTR3. Interacts with active ULK1 (phosphorylated on 'Ser-317') and BECN1 simultaneously. Also interacts with ATG16L1 (via WD repeats), and with ATG8 family members, including GABARAP, GABARAPL1 and, to a lesser extent, GABARAPL2, MAP1LC3A/LC3A and MAP1LC3C/LC3C. Interacts with TRIM21.
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production. It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization.
Cytoplasm Cytoskeleton Cell projection Ruffle Cell projection Lamellipodium Cytoplasm Cytoplasmic vesicle Autophagosome Nucleus Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (By similarity).
MANTRVDHLL | NTLEELLPYE | LEKFKFKLHT | TSLEKGHSRI | PLSLVKMARP |
IKLTRLLLTY | YGEEYAVRLT | LQILRATNQR | QLAEELHKAT | GPEHLTEENG |
VGGSVQSSAE | NKDKGVKGSD | VLGEDEAQQN | DDESDILPPI | QAEVGKGPQK |
KSLAKRKDQR | GPESLDSQTK | PGARSAAPLY | RRTLVTQSPG | DKENRAGAQT |
PQNAQLCREA | ARNSTAMSQG | GERSRRLKCI | CLQERSDPGV | LKLPLTQKKE |
NPQIQKLFRL | KRKQEMAVSF | VRETATLNGR | TTGTLEKGVG | IPEHSMMLDE |
ETSRNMSSKI | SLTREKRCTA | SWTENGNGGP | ETPETLGETV | SSILCDSCSP |
KVLLSLGEKL | AQTPEDPASL | GQAASKGRSR | DKVACPLCHT | QGELPAKACV |
QSSCSCSVAP | GDPKASGRCS | ICFQCQSSRA | GKSCEAQSPQ | FLPQCPRHMK |
QVQLLFCEDH | REPICLICRL | SQEHQGHRVR | PIEEAALQYK | EQIRKQLERL |
REMRGYVEEH | KLPADKKAED | FLKQTETQKQ | RISCPLEKLF | QFLEQQEQLF |
VTWLQELVQT | IGKVRETYYT | QVSLLDKLIG | ELEAKQDQPE | WELMQDIGAT |
LHRAETMTAS | ELLGIPPGVK | EKLHLLYQKS | KSAEKNMQRF | SEMLGSEMAF |
SASDVATREG | CRPSTTKAQA | LIPTVHLKCD | GAHTQDFDVI | LCAELEAGGS |
EPQDYLHPSS | AQDTPELHEI | HSQNNKRKFK | SFLKWKPSFS | RTDRCLRTCW |
This product has not yet been referenced specifically in any publications.
"MEFV mutations in patients with Familial Mediterranean Fever from the Aegean region of Turkey."
"MEFV gene mutations in Egyptian patients with familial Mediterranean fever."
"Prevalence and significance of MEFV gene mutations in a cohort of patients with rheumatoid arthritis."
"The spectrum of FMF mutations and genotypes in the referrals to molecular genetic laboratory at Kirikkale University in Turkey."
"Common MEFV mutations and polymorphisms in an elderly population: an association with E148Q polymorphism and rheumatoid factor levels."
"Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis."
"Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels."
"The clinical spectrum of 94 patients carrying a single mutated MEFV allele."
"MEFV mutation carriage in Israeli Jewish individuals from ethnicities with low risk for familial Mediterranean fever."
"Lack of association between E148Q MEFV variant and Kawasaki disease."
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