Mef2d (GeneName), Myocyte-specific enhancer factor 2D (ProteinName), MEF2D_MOUSE.
Mouse Mef2d/ Myocyte-specific enhancer factor 2D ELISA Kit
Natural and recombinant mouse Myocyte-specific enhancer factor 2D
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A (By similarity). Interacts with MAPK7; the interaction phosphorylates but does not activate MEF2D (By similarity). Interacts with MYOG. Interacts with CCAR2 and HDAC3.
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
Nucleus Translocated by HDAC4 to nuclear dots.
MGRKKIQIQR | ITDERNRQVT | FTKRKFGLMK | KAYELSVLCD | CEIALIIFNH |
SNKLFQYAST | DMDKVLLKYT | EYNEPHESRT | NADIIETLRK | KGFNGCDSPE |
PDGEDSLEQS | PLLEDKYRRA | SEELDGLFRR | YGSSVPAPNF | AMPVTVPVSN |
QSSMQFSNPS | SSLVTPSLVT | SSLTDPRLLS | PQQPALQRNS | VSPGLPQRPA |
SAGAMLGGDL | NSANGACPSP | VGNGYVSARA | SPGLLPVANG | NSLNKVIPAK |
SPPPPTHNTQ | LGAPSRKPDL | RVITSQGGKG | LMHHLTEDHL | DLNNAQRLGV |
SQSTHSLTTP | VVSVATPSLL | SQGLPFSSMP | TAYNTDYQLP | SAELSSLPAF |
SSPAGLALGN | VTAWQQPQPP | QQPQPPQPPQ | SQPQPPQPQP | QQPPQQQPHL |
VPVSLSNLIP | GSPLPHVGAA | LTVTTHPHIS | IKSEPVSPSR | ERSPAPPPPA |
VFPAARPEPG | EGLSSPAGGS | YETGDRDDGR | GDFGPTLGLL | RPAPEPEAEG |
SAVKRMRLDT | WTLK
This product has not yet been referenced specifically in any publications.
"A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage."
"Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation."
"Big mitogen-activated kinase regulates multiple members of the MEF2 protein family."
"Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals."
"Association of genetic variants with hemorrhagic stroke in Japanese individuals."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program."
"HDAC3 is negatively regulated by the nuclear protein DBC1."
"Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy."
"High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men."
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