MEF2C (基因名), Myocyte-specific enhancer factor 2C (蛋白名), MEF2C_BOVIN.
Bovine MEF2C/ Myocyte-specific enhancer factor 2C ELISA Kit
Natural and recombinant bovine Myocyte-specific enhancer factor 2C
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity). Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4 and HDAC9; the interaction with HDACs represses transcriptional activity (By similarity). Interacts with LPIN1. Interacts with MYOCD. Interacts with AKAP13 (By similarity). Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity.
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture.
MGRKKIQITR | IMDERNRQVT | FTKRKFGLMK | KAYELSVLCD | CEIALIIFNS |
TNKLFQYAST | DMDKVLLKYT | EYNEPHESRT | NSDIVETLRK | KGLNGCDSPD |
PDADDSVGHS | PESEDKYRKI | NEDIDLMISR | QRLCAVPPPN | FEMPVSIPVS |
SHNSLVYSNP | VSSLGNPNLL | PLAHPSLQRN | SMSPGVTHRP | PSAGNTGGLM |
GGDLTSGAGT | SAGNGYGNPR | NSPGLLVSPG | NLNKNMQAKS | PPPMNLGMNN |
RKPDLRVLIP | PGSKNTMPSV | SEDVDLLLNQ | RINNSQSAQS | LATPVVSVAT |
PTLPGQGMGG | YPSAISTTYG | TEYSLSSADL | SSLSGFNTAS | ALHLGSVTGW |
QQQHLHSMPP | SALSQLGDRT | TTPSRYPQHT | RHEAGRSPVD | SLSSCSSSYD |
GSDREDHRNE | FHSPIGLTRP | SPDERESPSV | KRMRLSEGWA | T
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