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MEF2C (GeneName), Myocyte-specific enhancer factor 2C (ProteinName), MEF2C_BOVIN.
Product Name:

Bovine MEF2C/ Myocyte-specific enhancer factor 2C ELISA Kit

Regulatory Status:
Detection Method:
Natural and recombinant bovine Myocyte-specific enhancer factor 2C
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Bovine MEF2C ELISA Kit
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Bovine MEF2C ELISA Kit
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Product Datasheets

General Annotation

Sub Unit:
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity). Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4 and HDAC9; the interaction with HDACs represses transcriptional activity (By similarity). Interacts with LPIN1. Interacts with MYOCD. Interacts with AKAP13 (By similarity). Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity.

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture.

Subcellular Location:

This product has not yet been referenced specifically in any publications.

"Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression."

"MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations."

"Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies."

"Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness."

"Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity."

"Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors."

"Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation."

"Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity."

"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."

"Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes."
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