MEF2A (GeneName), Myocyte-specific enhancer factor 2A (ProteinName), MEF2A_HUMAN.
Human MEF2A/ Myocyte-specific enhancer factor 2A ELISA Kit
Serum response factor-like protein 1, MEF2
Natural and recombinant human Myocyte-specific enhancer factor 2A
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Binds DNA as a homo- or heterodimer. Dimerizes with MEF2D. Interacts with HDAC7 (By similarity). Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A.
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
MGRKKIQITR | IMDERNRQVT | FTKRKFGLMK | KAYELSVLCD | CEIALIIFNS |
SNKLFQYAST | DMDKVLLKYT | EYNEPHESRT | NSDIVEALNK | KEHRGCDSPD |
PDTSYVLTPH | TEEKYKKINE | EFDNMMRNHK | IAPGLPPQNF | SMSVTVPVTS |
PNALSYTNPG | SSLVSPSLAA | SSTLTDSSML | SPPQTTLHRN | VSPGAPQRPP |
STGNAGGMLS | TTDLTVPNGA | GSSPVGNGFV | NSRASPNLIG | ATGANSLGKV |
MPTKSPPPPG | GGNLGMNSRK | PDLRVVIPPS | SKGMMPPLSE | EEELELNTQR |
ISSSQATQPL | ATPVVSVTTP | SLPPQGLVYS | AMPTAYNTDY | SLTSADLSAL |
QGFNSPGMLS | LGQVSAWQQH | HLGQAALSSL | VAGGQLSQGS | NLSINTNQNI |
SIKSEPISPP | RDRMTPSGFQ | QQQQQQQQQQ | PPPPPQPQPQ | PPQPQPRQEM |
GRSPVDSLSS | SSSSYDGSDR | EDPRGDFHSP | IVLGRPPNTE | DRESPSVKRM |
This product has not yet been referenced specifically in any publications.
"Transcription factor MEF2A mutations in patients with coronary artery disease."
"Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors."
"Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension."
"Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease."
"Lack of association between the MEF2A gene and myocardial infarction."
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