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MED8 (GeneName), Mediator of RNA polymerase II transcription subunit 8 (ProteinName), MED8_HUMAN.
Product Name:

Human MED8/ Mediator of RNA polymerase II transcription subunit 8 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Activator-recruited cofactor 32 kDa component, ARC32, Mediator complex subunit 8

Detection Method:
ELISA
Specificity:
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 8
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MED8 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. May be part of a multisubunit E3 ubiquitin-protein ligase complex with the elongin BC complex (ELOB and ELOC), CUL2 and RBX1.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase."

[2].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[3].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."

[6].
"Composite co-activator ARC mediates chromatin-directed transcriptional activation."

[7].
"Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways."

[8].
"Architecture of the human interactome defines protein communities and disease networks."

[9].
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."

[10].
"FBXW7 modulates cellular stress response and metastatic potential through ?HSF1 post-translational modification."
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