027-59234612(+86)
EIAab
Home  >  ELISA Kit  >  Mouse Med6 ELISA Kit
Med6 (GeneName), Mediator of RNA polymerase II transcription subunit 6 (ProteinName), MED6_MOUSE.
Product Name:

Mouse Med6/ Mediator of RNA polymerase II transcription subunit 6 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 6

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Mediator of RNA polymerase II transcription subunit 6
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Med6 ELISA Kit
Size & Price: Sign In.
×
Mouse Med6 ELISA Kit
Email *
Message *
Please Sign In.
Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and GLI3.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[2].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[4].
"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."

[5].
"TFIIH is negatively regulated by cdk8-containing mediator complexes."

[6].
"A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."

[7].
"Composite co-activator ARC mediates chromatin-directed transcriptional activation."

[8].
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."

[9].
"Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways."

[10].
"NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."
Close
Sample Data
Close
Sample Data
Close
Sample Data
My Cart close
Attention close
History close
Clear All
Comparison close
User
My Cart
Attention
History
Comparison
Top
Message
close_message
Product Name *
Email *
Message: *
Inform
new Message
Size Quantity Price ($) Subtotal 1 ($)
Subtotal 2: $
triangle
Size Quantity Price ($)
Do you want to be our agent and get a lower discount?
Please contact us:
Tel:027-59234612(+86)
Fax:027-59759960(+86)
Email:sales@eiaab.com