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Med30 (GeneName), Mediator of RNA polymerase II transcription subunit 30 (ProteinName), MED30_MOUSE.
Product Name:

Mouse Med30/ Mediator of RNA polymerase II transcription subunit 30 ELISA Kit

Cat.#:

E11532m

Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 30, Thyroid hormone receptor-associated protein 6, Thyroid hormone receptor-associated protein complex 25 kDa component, Trap25, Thrap6, Trap25

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Mediator of RNA polymerase II transcription subunit 30
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Med30 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis."

[2].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[3].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."

[6].
"Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s."

[7].
"Architecture of the human interactome defines protein communities and disease networks."

[8].
"The Contrasting Role of the Mediator Subunit MED30 in the Progression of Bladder Cancer."

[9].
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."

[10].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
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