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首页  >  酶联免疫试剂盒  >  Rat Med28 ELISA Kit
Med28 (基因名), Mediator of RNA polymerase II transcription subunit 28 (蛋白名), MED28_RAT.
产品名称:

Rat Med28/ Mediator of RNA polymerase II transcription subunit 28 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mediator complex subunit 28

检测方法:
ELISA
特异性:
Natural and recombinant rat Mediator of RNA polymerase II transcription subunit 28
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Med28 ELISA Kit
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Rat Med28 ELISA Kit
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产品说明书


通用注释


亚单元:
Forms a ternary complex with NF2/merlin and GRB2. Binds to actin (By similarity). Component of the Mediator complex, which is probably composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.


功能:
May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


亚细胞位置:
Nucleus Cytoplasm Membrane May be also cytoplasmic and membrane-associated.


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