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MED26 (GeneName), Mediator of RNA polymerase II transcription subunit 26 (ProteinName), MED26_HUMAN.
Product Name:

Human MED26/ Mediator of RNA polymerase II transcription subunit 26 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Activator-recruited cofactor 70 kDa component, ARC70, Cofactor required for Sp1 transcriptional activation subunit 7, CRSP complex subunit 7, Mediator complex subunit 26, Transcriptional coactivator CRSP70, ARC70, CRSP7

Detection Method:
ELISA
Specificity:
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 26
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MED26 ELISA Kit
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Human MED26 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated)(PubMed:20111005).


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."

[2].
"Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."

[3].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[4].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[5].
"Composite co-activator ARC mediates chromatin-directed transcriptional activation."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination."

[8].
"Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7."

[9].
"Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis."

[10].
"1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26."
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