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MED25 (GeneName), Mediator of RNA polymerase II transcription subunit 25 (ProteinName), MED25_HUMAN.
Product Name:

Human MED25/ Mediator of RNA polymerase II transcription subunit 25 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Activator interaction domain-containing protein 1, Activator-recruited cofactor 92 kDa component, ARC92, Mediator complex subunit 25, p78, ACID1, ARC92, PTOV2, TCBAP0758

Detection Method:
ELISA
Specificity:
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 25
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MED25 ELISA Kit
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Human MED25 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CREBBP. Interacts with ESR1, GR, RARA, RXRA and THRB in a ligand-dependent fashion. Binds the Herpes simplex virus activator VP16.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models."

[2].
"A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein."

[3].
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."

[4].
"Homozygous missense mutation in MED25 segregates with syndromic intellectual disability in a large consanguineous family."

[5].
"Homozygous MED25 mutation implicated in eye-intellectual disability syndrome."

[6].
"NMR structure of the human Mediator MED25 ACID domain."

[7].
"MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation."

[8].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[9].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[10].
"The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator."
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