MED24 (GeneName), Mediator of RNA polymerase II transcription subunit 24 (ProteinName), MED24_HUMAN.
Human MED24/ Mediator of RNA polymerase II transcription subunit 24 ELISA Kit
Activator-recruited cofactor 100 kDa component, ARC100, Cofactor required for Sp1 transcriptional activation subunit 4, CRSP complex subunit 4, Mediator complex subunit 24, Thyroid hormone receptor-associated protein 4, Thyroid hormone receptor-associated protein complex 100 kDa component, Trap100, Vitamin D3 receptor-interacting protein complex 100 kDa component, DRIP100, ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 24
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
MKVVNLKQAI | LQAWKERWSD | YQWAINMKKF | FPKGATWDIL | NLADALLEQA |
MIGPSPNPLI | LSYLKYAISS | QMVSYSSVLT | AISKFDDFSR | DLCVQALLDI |
MDMFCDRLSC | HGKAEECIGL | CRALLSALHW | LLRCTAASAE | RLREGLEAGT |
PAAGEKQLAM | CLQRLEKTLS | STKNRALLHI | AKLEEASSWT | AIEHSLLKLG |
EILANLSNPQ | LRSQAEQCGT | LIRSIPTMLS | VHAEQMHKTG | FPTVHAVILL |
EGTMNLTGET | QSLVEQLTMV | KRMQHIPTPL | FVLEIWKACF | VGLIESPEGT |
EELKWTAFTF | LKIPQVLVKL | KKYSHGDKDF | TEDVNCAFEF | LLKLTPLLDK |
ADQRCNCDCT | NFLLQECGKQ | GLLSEASVNN | LMAKRKADRE | HAPQQKSGEN |
ANIQPNIQLI | LRAEPTVTNI | LKTMDADHSK | SPEGLLGVLG | HMLSGKSLDL |
LLAAAAATGK | LKSFARKFIN | LNEFTTYGSE | ESTKPASVRA | LLFDISFLML |
CHVAQTYGSE | VILSESRTGA | EVPFFETWMQ | TCMPEEGKIL | NPDHPCFRPD |
STKVESLVAL | LNNSSEMKLV | QMKWHEACLS | ISAAILEILN | AWENGVLAFE |
SIQKITDNIK | GKVCSLAVCA | VAWLVAHVRM | LGLDEREKSL | QMIRQLAGPL |
FSENTLQFYN | ERVVIMNSIL | ERMCADVLQQ | TATQIKFPST | GVDTMPYWNL |
LPPKRPIKEV | LTDIFAKVLE | KGWVDSRSIH | IFDTLLHMGG | VYWFCNNLIK |
ELLKETRKEH | TLRAVELLYS | IFCLDMQQVT | LVLLGHILPG | LLTDSSKWHS |
LMDPPGTALA | KLAVWCALSS | YSSHKGQAST | RQKKRHREDI | EDYISLFPLD |
DVQPSKLMRL | LSSNEDDANI | LSSPTDRSMS | SSLSASQLHT | VNMRDPLNRV |
LANLFLLISS | ILGSRTAGPH | TQFVQWFMEE | CVDCLEQGGR | GSVLQFMPFT |
TVSELVKVSA | MSSPKVVLAI | TDLSLPLGRQ | VAAKAIAAL
This product has not yet been referenced specifically in any publications.
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
"A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression."
"A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
"Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."
"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
"Composite co-activator ARC mediates chromatin-directed transcriptional activation."
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