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MED24 (GeneName), Mediator of RNA polymerase II transcription subunit 24 (ProteinName), MED24_CHICK.
Product Name:

Chicken MED24/ Mediator of RNA polymerase II transcription subunit 24 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 24, RCJMB04_13m7

Detection Method:
ELISA
Specificity:
Natural and recombinant chicken Mediator of RNA polymerase II transcription subunit 24
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Chicken MED24 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[2].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[3].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."

[6].
"A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression."

[7].
"A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."

[8].
"Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."

[9].
"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."

[10].
"Composite co-activator ARC mediates chromatin-directed transcriptional activation."
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