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Med23 (GeneName), Mediator of RNA polymerase II transcription subunit 23 (ProteinName), MED23_MOUSE.
Product Name:

Mouse Med23/ Mediator of RNA polymerase II transcription subunit 23 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23, Protein sur-2 homolog, mSur-2, Crsp3, Kiaa1216, Sur2

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Mediator of RNA polymerase II transcription subunit 23
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Med23 ELISA Kit
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Mouse Med23 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated), CTNNB1, and GLI3. Interacts with CDK8 and ELK1.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."

[2].
"MED23 mutation links intellectual disability to dysregulation of immediate early gene expression."

[3].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[4].
"Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."

[5].
"Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations."

[6].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[7].
"Ras induces mediator complex exchange on C/EBP beta."

[8].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[9].
"The DNA sequence and analysis of human chromosome 6."

[10].
"Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP."
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