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Med21 (GeneName), Mediator of RNA polymerase II transcription subunit 21 (ProteinName), MED21_MOUSE.
Product Name:

Mouse Med21/ Mediator of RNA polymerase II transcription subunit 21 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 21, RNA polymerase II holoenzyme component SRB7, RNAPII complex component SRB7, Srb7, Surb7

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Mediator of RNA polymerase II transcription subunit 21
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Med21 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion (By similarity). Interacts with PPARG.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."

[2].
"A mammalian SRB protein associated with an RNA polymerase II holoenzyme."

[3].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[4].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[5].
"hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."

[8].
"A human RNA polymerase II complex associated with SRB and DNA-repair proteins."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."
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