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Med20 (GeneName), Mediator of RNA polymerase II transcription subunit 20 (ProteinName), MED20_RAT.
Product Name:

Rat Med20/ Mediator of RNA polymerase II transcription subunit 20 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 20, TRF-proximal protein homolog, Trfp

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Mediator of RNA polymerase II transcription subunit 20
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Rat Med20 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with PPARG.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[2].
"The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex."

[3].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."

[7].
"The DNA sequence and analysis of human chromosome 6."

[8].
"Architecture of the human interactome defines protein communities and disease networks."

[9].
"All three human scavenger receptor class B proteins can bind and transport all three macular xanthophyll carotenoids."

[10].
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."
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