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首页  >  酶联免疫试剂盒  >  Mouse Med1 ELISA Kit
Med1 (基因名), Mediator of RNA polymerase II transcription subunit 1 (蛋白名), MED1_MOUSE.
产品名称:

Mouse Med1/ Mediator of RNA polymerase II transcription subunit 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mediator complex subunit 1, Peroxisome proliferator-activated receptor-binding protein, PBP, Thyroid hormone receptor-associated protein complex 220 kDa component, Trap220, Thyroid receptor-interacting protein 2, TR-interacting protein 2, Crsp210, Drip205, Pbp, Pparbp, Trap220, Trip2

检测方法:
ELISA
特异性:
Natural and recombinant mouse Mediator of RNA polymerase II transcription subunit 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cardiovascular
Mouse Med1 ELISA Kit
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Mouse Med1 ELISA Kit
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产品说明书


通用注释


亚单元:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with GATA1 and YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3. Interacts with CCAR1 (By similarity). Interacts with NR4A3 (PubMed:12709428).


功能:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells.


亚细胞位置:
Nucleus A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.


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