MED1 (GeneName), Mediator of RNA polymerase II transcription subunit 1 (ProteinName), MED1_HUMAN.
Human MED1/ Mediator of RNA polymerase II transcription subunit 1 ELISA Kit
Activator-recruited cofactor 205 kDa component, ARC205, Mediator complex subunit 1, Peroxisome proliferator-activated receptor-binding protein, PBP, Thyroid hormone receptor-associated protein complex 220 kDa component, Trap220, Thyroid receptor-interacting protein 2, TR-interacting protein 2, Vitamin D receptor-interacting protein complex component DRIP205, p53 regulatory protein RB18A, ARC205, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3 (By similarity). Interacts with GATA1 and CCAR1. Interacts with NR4A3 (By similarity).
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Nucleus A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.
MKAQGETEES | EKLSKMSSLL | ERLHAKFNQN | RPWSETIKLV | RQVMEKRVVM |
SSGGHQHLVS | CLETLQKAL | KVTSLPAMTD | RLESIARQNG | LGSHLSASGT |
ECYITSDMFY | VEVQLDPAGQ | L CDVKVAHH | GENPVSCPEL | VQQLREKNFD |
EFSKHLKGLV | NLYNLPGDNK | LKTKMYLALQ | SL EQDLSKM | AIMYWKATNA |
GPLDKILHGS | VGYLTPRSGG | HLMNLKYYVS | PSDLLDDKTA | SPI ILHENN |
VSRSLGMNAS | VTIEGTSAVY | KLPIAPLIMG | SHPVDNKWTP | SFSSITSANS |
VDLP ACFFL | KFPQPIPVSR | AFVQKLQNCT | GIPLFETQPT | YAPLYELITQ |
FELSKDPDPI | PLNHN MRFY | AALPGQQHCY | FLNKDAPLPD | GRSLQGTLVS |
KITFQHPGRV | PLILNLIRHQ | VAYNTL IGS | CVKRTILKED | SPGLLQFEVC |
PLSESRFSVS | FQHPVNDSLV | CVVMDVQDST | HVSCKLY KG | LSDALICTDD |
FIAKVVQRCM | SIPVTMRAIR | RKAETIQADT | PALSLIAETV | EDMVKKNL P |
PASSPGYGMT | TGNNPMSGTT | TPTNTFPGGP | ITTLFNMSMS | IKDRHESVGH |
GEDFSKVSQ | NPILTSLLQI | TGNGGSTIGS | SPTPPHHTPP | PVSSMAGNTK |
NHPMLMNLLK | DNPAQDFSTL | YGSSPLERQ | NSSSGSPRME | ICSGSNKTKK |
KKSSRLPPEK | PKHQTEDDFQ | RELFSMDVDS | Q NPIFDVNM | TADTLDTPHI |
TPAPSQCSTP | PTTYPQPVPH | PQPSIQRMVR | LSSSDSIGPD | VT DILSDIA |
EEASKLPSTS | DDCPAIGTPL | RDSSSSGHSQ | STLFDSDVFQ | TNNNENPYTD |
PAD LIADAA | GSPSSDSPTN | HFFHDGVDFN | PDLLNSQSQS | GFGEEYFDES |
SQSGDNDDFK | GFAS QALNT | LGVPMLGGDN | GETKFKGNNQ | ADTVDFSIIS |
VAGKALAPAD | LMEHHSGSQG | PLLTT GDLG | KEKTQKRVKE | GNGTSNSTLS |
GPGLDSKPGK | RSRTPSNDGK | SKDKPPKRKK | ADTEGK SPS | HSSSNRPFTP |
PTSTGGSKSP | GSAGRSQTPP | GVATPPIPKI | TIQIPKGTVM | VGKPSSH SQ |
YTSSGSVSSS | GSKSHHSHSS | SSSSSASTSG | KMKSSKSEGS | SSSKLSSSMY |
SSQGSSGS S | QSKNSSQSGG | KPGSSPITKH | GLSSGSSSTK | MKPQGKPSSL |
MNPSLSKPNI | SPSHSRPPG | GSDKLASPMK | PVPGTPPSSK | AKSPISSGSG |
GSHMSGTSSS | SGMKSSSGLG | SSGSLSQKTP | PSSNSCTAS | SSSFSSSGSS |
MSSSQNQHGS | SKGKSPSRNK | KPSLTAVIDK | LKHGVVTSGP | G GEDPLDGQ |
MGVSTNSSSH | PMSSKHNMSG | GEFQGKREKS | DKDKSKVSTS | GSSVDSSKKT |
SE SKNVGST | GVAKIIISKH | DGGSPSIKAK | VTLQKPGESS | GEGLRPQMAS |
SKNYGSPLIS | GST PKHERG | SPSHSKSPAY | TPQNLDSESE | SGSSIAEKSY |
QNSPSSDDGI | RPLPEYSTEK | HKKH KKEKK | KVKDKDRDRD | RDKDRDKKKS |
HSIKPESWSK | SPISSDQSLS | MTSNTILSAD | RPSRL SPDF | MIGEEDDDLM |
This product has not yet been referenced specifically in any publications.
"Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort."
"Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins."
"Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha."
"A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression."
"Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex."
"The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes."
"Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer."
"The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion."
"CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function."
"Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study."
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