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MED19 (GeneName), Mediator of RNA polymerase II transcription subunit 19 (ProteinName), MED19_HUMAN.
Product Name:

Human MED19/ Mediator of RNA polymerase II transcription subunit 19 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Lung cancer metastasis-related protein 1, Mediator complex subunit 19, LCMR1

Detection Method:
ELISA
Specificity:
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 19
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MED19 ELISA Kit
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Human MED19 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[2].
"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."

[3].
"Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method."

[4].
"Architecture of the human interactome defines protein communities and disease networks."

[5].
"LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells."

[6].
"Knockdown of mediator subunit Med19 suppresses bladder cancer cell proliferation and migration by downregulating Wnt/β-catenin signalling pathway."

[7].
"Knockdown of Mediator Complex Subunit 19 Suppresses the Growth and Invasion of Prostate Cancer Cells."

[8].
"Med19 promotes breast cancer cell proliferation by regulating CBFA2T3/HEB expression."

[9].
"A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion."

[10].
"The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer."
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