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MED18 (GeneName), Mediator of RNA polymerase II transcription subunit 18 (ProteinName), MED18_BOVIN.
Product Name:

Bovine MED18/ Mediator of RNA polymerase II transcription subunit 18 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 18

Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Mediator of RNA polymerase II transcription subunit 18
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Bovine MED18 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[2].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[3].
"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."

[4].
"Architecture of the human interactome defines protein communities and disease networks."

[5].
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."

[6].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[7].
"Panorama of ancient metazoan macromolecular complexes."

[8].
"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."

[9].
"Subunit architecture and functional modular rearrangements of the transcriptional mediator complex."

[10].
"A proteome-scale map of the human interactome network."
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