MED17 (GeneName), Mediator of RNA polymerase II transcription subunit 17 (ProteinName), MED17_HUMAN.
Human MED17/ Mediator of RNA polymerase II transcription subunit 17 ELISA Kit
Activator-recruited cofactor 77 kDa component, ARC77, Cofactor required for Sp1 transcriptional activation subunit 6, CRSP complex subunit 6, Mediator complex subunit 17, Thyroid hormone receptor-associated protein complex 80 kDa component, Trap80, Transcriptional coactivator CRSP77, Vitamin D3 receptor-interacting protein complex 80 kDa component, DRIP80, ARC77, CRSP6, DRIP77, DRIP80, TRAP80
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 17
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
MSGVRAVRIS | IESACEKQVH | EVGLDGTETY | LPPLSMSQNL | ARLAQRIDFS |
QGSGSEEEEA | AGTEGDAQEW | PGAGSSADQD | DEEGVVKFQP | SLWPWDSVRN |
NLRSALTEMC | VLYDVLSIVR | DKKFMTLDPV | SQDALPPKQN | PQTLQLISKK |
KSLAGAAQIL | LKGAERLTKS | VTENQENKLQ | RDFNSELLRL | RQHWKLRKVG |
DKILGDLSYR | SAGSLFPHHG | TFEVIKNTDL | DLDKKIPEDY | CPLDVQIPSD |
LEGSAYIKVS | IQKQAPDIGD | LGTVNLFKRP | LPKSKPGSPH | WQTKLEAAQN |
VLLCKEIFAQ | LSREAVQIKS | QVPHIVVKNQ | IISQPFPSLQ | LSISLCHSSN |
DKKSQKFATE | KQCPEDHLYV | LEHNLHLLIR | EFHKQTLSSI | MMPHPASAPF |
GHKRMRLSGP | QAFDKNEINS | LQSSEGLLEK | IIKQAKHIFL | RSRAAATIDS |
LASRIEDPQI | QAHWSNINDV | YESSVKVLIT | SQGYEQICKS | IQLQLNIGVE |
QIRVVHRDGR | VITLSYQEQE | LQDFLLSQMS | QHQVHAVQQL | AKVMGWQVLS |
FSNHVGLGPI | ESIGNASAIT | VASPSGDYAI | SVRNGPESGS | KIMVQFPRNQ |
CKDLPKSDVL | QDNKWSHLRG | PFKEVQWNKM | EGRNFVYKME | LLMSALSPCL |
This product has not yet been referenced specifically in any publications.
"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."
"Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."
"Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex."
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Role of metazoan mediator proteins in interferon-responsive transcription."
"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."
"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
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