MED16 (GeneName), Mediator of RNA polymerase II transcription subunit 16 (ProteinName), MED16_HUMAN.
Human MED16/ Mediator of RNA polymerase II transcription subunit 16 ELISA Kit
Mediator complex subunit 16, Thyroid hormone receptor-associated protein 5, Thyroid hormone receptor-associated protein complex 95 kDa component, Trap95, Vitamin D3 receptor-interacting protein complex 92 kDa component, DRIP92, DRIP92, THRAP5
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 16
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
MCDLRRPAAG | GMMDLAYVCE | WEKWSKSTHC | PSVPLACAWS | CRNLIAFTMD |
LRSDDQDLTR | MIHILDTEHP | WDLHSIPSEH | HEAITCLEWD | QSGSRLLSAD |
ADGQIKCWSM | ADHLANSWES | SVGSLVEGDP | IVALSWLHNG | VKLALHVEKS |
GASSFGEKFS | RVKFSPSLTL | FGGKPMEGWI | AVTVSGLVTV | SLLKPSGQVL |
TSTESLCRLR | GRVALADIAF | TGGGNIVVAT | ADGSSASPVQ | FYKVCVSVVS |
EKCRIDTEIL | PSLFMRCTTD | LNRKDKFPAI | THLKFLARDM | SEQVLLCASS |
QTSSIVECWS | LRKEGLPVNN | IFQQISPVVG | DKQPTILKWR | ILSATNDLDR |
VSAVALPKLP | ISLTNTDLKV | ASDTQFYPGL | GLALAFHDGS | VHIVHRLSLQ |
TMAVFYSSAA | PRPVDEPAMK | RPRTAGPAVH | LKAMQLSWTS | LALVGIDSHG |
KLSVLRLSPS | MGHPLEVGLA | LRHLLFLLEY | CMVTGYDWWD | ILLHVQPSMV |
QSLVEKLHEE | YTRQTAALQQ | VLSTRILAMK | ASLCKLSPCT | VTRVCDYHTK |
LFLIAISSTL | KSLLRPHFLN | TPDKSPGDRL | TEICTKITDV | DIDKVMINLK |
TEEFVLDMNT | LQALQQLLQW | VGDFVLYLLA | SLPNQGSLLR | PGHSFLRDGT |
SLGMLRELMV | VIRIWGLLKP | SCLPVYTATS | DTQDSMSLLF | RLLTKLWICC |
RDEGPASEPD | EALVDECCLL | PSQLLIPSLD | WLPASDGLVS | RLQPKQPLRL |
QFGRAPTLPG | SAATLQLDGL | ARAPGQPKID | HLRRLHLGAC | PTEECKACTR |
CGCVTMLKSP | NRTTAVKQWE | QRWIKNCLAV | EGRGPDACVT | SRASEEAPAF |
VQLGPQSTHH | SPRTPRSLDH | LHPEDRP
This product has not yet been referenced specifically in any publications.
"Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."
"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."
"FBXW7 modulates cellular stress response and metastatic potential through ?HSF1 post-translational modification."
"Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation."
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
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