MED14 (GeneName), Mediator of RNA polymerase II transcription subunit 14 (ProteinName), MED14_HUMAN.
Human MED14/ Mediator of RNA polymerase II transcription subunit 14 ELISA Kit
Activator-recruited cofactor 150 kDa component, ARC150, Cofactor required for Sp1 transcriptional activation subunit 2, CRSP complex subunit 2, Mediator complex subunit 14, RGR1 homolog, hRGR1, Thyroid hormone receptor-associated protein complex 170 kDa component, Trap170, Transcriptional coactivator CRSP150, Vitamin D3 receptor-interacting protein complex 150 kDa component, DRIP150, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170
Natural and recombinant human Mediator of RNA polymerase II transcription subunit 14
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
MAPVQLENHQ | LVPPGGGGGG | SGGPPSAPAP | PPPGAAVAAA | AAAAASPGYR |
LSTLIEFLLH | RAYSELMVL | TDLLPRKSDV | ERKIEIVQFA | SRTRQLFVRL |
LALVKWANNA | GKVEKCAMIS | S FLDQQAIL | FVDTADRLAS | LARDALVHAR |
LPSFAIPYAI | DVLTTGSYPR | LPTCIRDKII | PP DPITKIE | KQATLHQLNQ |
ILRHRLVTTD | LPPQLANLTV | ANGRVKFRVE | GEFEATLTVM | GDD PDVPWR |
LLKLEILVED | KETGDGRALV | HSMQISFIHQ | LVQSRLFADE | KPLQDMYNCL |
HSFC LSLQL | EVLHSQTLML | IRERWGDLVQ | VERYHAGKCL | SLSVWNQQVL |
GRKTGTASVH | KVTIK IDEN | DVSKPLQIFH | DPPLPASDSK | LVERAMKIDH |
LSIEKLLIDS | VHARAHQKLQ | ELKAIL RGF | NANENSSIET | ALPALVVPIL |
EPCGNSECLH | IFVDLHSGMF | QLMLYGLDQA | TLDDMEK SV | NDDMKRIIPW |
IQQLKFWLGQ | QRCKQSIKHL | PTISSETLQL | SNYSTHPIGN | LSKNKLFI K |
LTRLPQYYIV | VEMLEVPNKP | TQLSYKYYFM | SVNAADREDS | PAMALLLQQF |
KENIQDLVF | RTKTGKQTRT | NAKRKLSDDP | CPVESKKTKR | AGEMCAFNKV |
LAHFVAMCDT | NMPFVGLRLE | LSNLEIPHQ | GVQVEGDGFS | HAIRLLKIPP |
CKGITEETQK | ALDRSLLDCT | FRLQGRNNRT | W VAELVFAN | CPLNGTSTRE |
QGPSRHVYLT | YENLLSEPVG | GRKVVEMFLN | DWNSIARLYE | CV LEFARSL |
PDIPAHLNIF | SEVRVYNYRK | LILCYGTTKG | SSISIQWNSI | HQKFHISLGT |
VGP NSGCSN | CHNTILHQLQ | EMFNKTPNVV | QLLQVLFDTQ | APLNAINKLP |
TVPMLGLTQR | TNTA YQCFS | ILPQSSTHIR | LAFRNMYCID | IYCRSRGVVA |
IRDGAYSLFD | NSKLVEGFYP | APGLK TFLN | MFVDSNQDAR | RRSVNEDDNP |
PSPIGGDMMD | SLISQLQPPP | QQQPFPKQPG | TSGAYP LTS | PPTSYHSTVN |
QSPSMMHTQS | PGNLHAASSP | SGALRAPSPA | SFVPTPPPSS | HGISIGP GA |
SFASPHGTLD | PSSPYTMVSP | SGRAGNWPGS | PQVSGPSPAA | RMPGMSPANP |
SLHSPVPD A | SHSPRAGTSS | QTMPTNMPPP | RKLPQRSWAA | SIPTILTHSA |
LNILLLPSPT | PGLVPGLAG | SYLCSPLERF | LGSVIMRRHL | QRIIQQETLQ |
LINSNEPGVI | MFKTDALKCR | VALSPKTNQT | LQLKVTPEN | AGQWKPDELQ |
VLEKFFETRV | AGPPFKANTL | IAFTKLLGAP | THILRDCVHI | M KLELFPDQ |
ATQLKWNVQF | CLTIPPSAPP | IAPPGTPAVV | LKSKMLFFLQ | LTQKTSVPPQ |
EP VSIIVPI | IYDMASGTTQ | QADIPRQQNS | SVAAPMMVSN | ILKRFAEMNP |
PRQGECTIFA | AVR DLMANL | TLPPGGRP
This product has not yet been referenced specifically in any publications.
"DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs."
"Role of metazoan mediator proteins in interferon-responsive transcription."
"A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression."
"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."
"Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method."
"Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150)."
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
"Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4."
"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
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