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Med12 (GeneName), Mediator of RNA polymerase II transcription subunit 12 (ProteinName), MED12_MOUSE.
Product Name:

Mouse Med12/ Mediator of RNA polymerase II transcription subunit 12 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 12, OPA-containing protein, Thyroid hormone receptor-associated protein complex 230 kDa component, Trap230, Trinucleotide repeat-containing gene 11 protein, Kiaa0192, Mopa, Tnrc11, Trap230

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Mediator of RNA polymerase II transcription subunit 12
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Med12 ELISA Kit
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Mouse Med12 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Also interacts with CTNNB1 and GLI3.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome."

[2].
"The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene."

[3].
"No association of a dodecamer duplication in the human opposite paired (HOPA) gene with mental retardation and schizophrenia in Chinese patients from Taiwan."

[4].
"Association studies of the HOPA dodecamer duplication variant in different subtypes of autism."

[5].
"The association of a HOPA polymorphism with major depression and phobia."

[6].
"Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism."

[7].
"Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."

[8].
"The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA)."

[9].
"cDNAs with long CAG trinucleotide repeats from human brain."

[10].
"Mutations in MED12 cause X-linked Ohdo syndrome."
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