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MED11 (GeneName), Mediator of RNA polymerase II transcription subunit 11 (ProteinName), MED11_BOVIN.
Product Name:

Bovine MED11/ Mediator of RNA polymerase II transcription subunit 11 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 11

Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Mediator of RNA polymerase II transcription subunit 11
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Bovine MED11 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.


Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."

[2].
"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."

[3].
"MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."

[4].
"Architecture of the human interactome defines protein communities and disease networks."

[5].
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."

[6].
"FBXW7 modulates cellular stress response and metastatic potential through ?HSF1 post-translational modification."

[7].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[8].
"Panorama of ancient metazoan macromolecular complexes."

[9].
"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."

[10].
"Characterization of the influence of mediator complex in HIV-1 transcription."
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