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Mecr (GeneName), Enoyl-[acyl-carrier-protein] reductase, mitochondrial (ProteinName), MECR_RAT.
Product Name:

Rat Mecr/ Enoyl-[acyl-carrier-protein] reductase, mitochondrial ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

2-enoyl thioester reductase, Nuclear receptor-binding factor 1, NRBF-1, Nrbf1

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
Rat Mecr ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homodimer (By similarity). Isoform 2 interacts with PPARA in the nucleus and increases its activity (PubMed:25031892).


Function:
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16).


Subcellular Location:
Isoform 2 Cytoplasm Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II."

[2].
"Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties."

[3].
"MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder."

[4].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[5].
"The DNA sequence and biological annotation of human chromosome 1."

[6].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."

[9].
"Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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