MECR (GeneName), Enoyl-[acyl-carrier-protein] reductase, mitochondrial (ProteinName), MECR_BOVIN.
Bovine MECR/ Enoyl-[acyl-carrier-protein] reductase, mitochondrial ELISA Kit
2-enoyl thioester reductase, Nuclear receptor-binding factor 1, BtNrbf-1, NBRF1
Natural and recombinant bovine Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16).
MWVCGALCRT | RAPAQLGQRL | LPESRRRRPA | SASFSASAEP | SRVRALVYGH |
HGDPAKVVEL | KNLELAAVGG | SHVHVKMLAA | PINPSDINMI | QGNYGLLPQL |
PAVGGNEGVG | QVVAVGSGVT | GVKPGDWVIP | ANPGLGTWRT | EAVFGEEELI |
TVPSDIPLQS | AATLGVNPCT | AYRMLVDFER | LRPRDSIIQN | ASNSGVGQAV |
IQIAAARGLR | TINVLRDTPD | LQKLTDTLKN | LGANHVVTEE | ELRKPEMKSF |
FKDVPQPRLA | LNCVGGKSST | ELLRHLAPGG | TMVTYGGMAK | QPVIASVSQL |
IFKDLKLRGF | WLSQWKKDHS | PDQFKELILT | LCDLIRRGQL | TAPACSEVPL |
QDYLCALEAS | TQPFVSSKQI | LTM
This product has not yet been referenced specifically in any publications.
"Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II."
"Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties."
"MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder."
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
"The DNA sequence and biological annotation of human chromosome 1."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
"Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors."
"Architecture of the human interactome defines protein communities and disease networks."
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