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首页  >  酶联免疫试剂盒  >  Human MDN1 ELISA Kit
MDN1 (基因名), Midasin (蛋白名), MDN1_HUMAN.
产品名称:

Human MDN1/ Midasin ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

KIAA0301, Dynein-related AAA-ATPase MDN1, MIDAS-containing protein

检测方法:
ELISA
特异性:
Natural and recombinant human Midasin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MDN1 ELISA Kit
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Human MDN1 ELISA Kit
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产品说明书


通用注释


亚单元:
Associates with pre-60S ribosomes in the nucleoplasm. Interacts (via its hexameric AAA ATPase ring) with the PELP1 complex (via PELP1); the interaction is regulated by SUMO conjugation of PELP1 and is crucial for recruitment of MDN1 to the pre-ribosomal particle (PubMed:27814492). Interacts (via VWFA/MIDAS domain) with WDR12 (via UBL domain) (PubMed:26601951). Interacts (via VWFA/MIDAS domain) with NLE1 (via UBL domain) (PubMed:26601951).


功能:
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).


亚细胞位置:
Nucleus Nucleolus Nucleus Nucleoplasm Cytoplasm


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