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MDN1 (GeneName), Midasin (ProteinName), MDN1_HUMAN.
Product Name:

Human MDN1/ Midasin ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

KIAA0301, Dynein-related AAA-ATPase MDN1, MIDAS-containing protein

Detection Method:
ELISA
Specificity:
Natural and recombinant human Midasin
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MDN1 ELISA Kit
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Human MDN1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Associates with pre-60S ribosomes in the nucleoplasm. Interacts (via its hexameric AAA ATPase ring) with the PELP1 complex (via PELP1); the interaction is regulated by SUMO conjugation of PELP1 and is crucial for recruitment of MDN1 to the pre-ribosomal particle (PubMed:27814492). Interacts (via VWFA/MIDAS domain) with WDR12 (via UBL domain) (PubMed:26601951). Interacts (via VWFA/MIDAS domain) with NLE1 (via UBL domain) (PubMed:26601951).


Function:
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity).


Subcellular Location:
Nucleus Nucleolus Nucleus Nucleoplasm Cytoplasm


This product has not yet been referenced specifically in any publications.

[1].
"Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein."

[2].
"The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin."

[3].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

[4].
"The DNA sequence and analysis of human chromosome 6."

[5].
"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."

[8].
"Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development."

[9].
"The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling."

[10].
"Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes."
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