Mdm4 (GeneName), Protein Mdm4 (ProteinName), MDM4_MOUSE.
Mouse Mdm4/ Protein Mdm4 ELISA Kit
Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, Mdmx
Natural and recombinant mouse Protein Mdm4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts with USP2. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53 (By similarity). Interacts with MDM2, TP53 and TP73.
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.
MTSHSTSAQC | SASDSACRIS | SEQISQVRPK | LQLLKILHAA | GAQGEVFTMK |
EVMHYLGQYI | MVKQLYDQQE | QHMVYCGGDL | LGDLLGCQSF | SVKDPSPLYD |
MLRKNLVTSA | SINTDAAQTL | ALAQDHTMDF | PSQDRLKHGA | TEYSNPRKRT |
EEEDTHTLPT | SRHKCRDSRA | DEDLIEHLSQ | DETSRLDLDF | EEWDVAGLPW |
WFLGNLRNNC | IPKSNGSTDL | QTNQDIGTAI | VSDTTDDLWF | LNETVSEQLG |
VGIKVEAANS | EQTSEVGKTS | NKKTVEVGKD | DDLEDSRSLS | DDTDVELTSE |
DEWQCTECKK | FNSPSKRYCF | RCWALRKDWY | SDCSKLTHSL | STSNITAIPE |
KKDNEGIDVP | DCRRTISAPV | VRPKDGYLKE | EKPRFDPCNS | VGFLDLAHSS |
ESQEIISSAR | EQTDIFSEQK | AETESMEDFQ | NVLKPCSLCE | KRPRDGNIIH |
GKTSHLTTCF | HCARRLKKSG | ASCPACKKEI | QLVIKVFIA
This product has not yet been referenced specifically in any publications.
"Isolation and identification of the human homolog of a new p53-binding protein, Mdmx."
"MdmX is a substrate for the deubiquitinating enzyme USP2a."
"14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."
"ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage."
"The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."
"MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer."
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