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Mdm4 (GeneName), Protein Mdm4 (ProteinName), MDM4_MOUSE.
Product Name:

Mouse Mdm4/ Protein Mdm4 ELISA Kit

Cat.#:

E12870m

Brand:
EIAab®
Regulatory Status:
Alternative:

Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, Mdmx

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Protein Mdm4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
Mouse Mdm4 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts with USP2. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53 (By similarity). Interacts with MDM2, TP53 and TP73.


Function:
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Isolation and identification of the human homolog of a new p53-binding protein, Mdmx."

[2].
"MdmX is a substrate for the deubiquitinating enzyme USP2a."

[3].
"14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."

[4].
"ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage."

[5].
"The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans."

[6].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[7].
"Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."

[10].
"MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer."
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