MDM4 (GeneName), Protein Mdm4 (ProteinName), MDM4_HUMAN.
Human MDM4/ Protein Mdm4 ELISA Kit
Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDMX
Natural and recombinant human Protein Mdm4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53.
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
MTSFSTSAQC | STSDSACRIS | PGQINQVRPK | LPLLKILHAA | GAQGEMFTVK |
EVMHYLGQYI | MVKQLYDQQE | QHMVYCGGDL | LGELLGRQSF | SVKDPSPLYD |
MLRKNLVTLA | TATTDAAQTL | ALAQDHSMDI | PSQDQLKQSA | EESSTSRKRT |
TEDDIPTLPT | SEHKCIHSRE | DEDLIENLAQ | DETSRLDLGF | EEWDVAGLPW |
WFLGNLRSNY | TPRSNGSTDL | QTNQDVGTAI | VSDTTDDLWF | LNESVSEQLG |
VGIKVEAADT | EQTSEEVGKV | SDKKVIEVGK | NDDLEDSKSL | SDDTDVEVTS |
EDEWQCTECK | KFNSPSKRYC | FRCWALRKDW | YSDCSKLTHS | LSTSDITAIP |
EKENEGNDVP | DCRRTISAPV | VRPKDAYIKK | ENSKLFDPCN | SVEFLDLAHS |
SESQETISSM | GEQLDNLSEQ | RTDTENMEDC | QNLLKPCSLC | EKRPRDGNII |
HGRTGHLVTC | FHCARRLKKA | GASCPICKKE | IQLVIKVFIA |
This product has not yet been referenced specifically in any publications.
"Isolation and identification of the human homolog of a new p53-binding protein, Mdmx."
"MdmX is a substrate for the deubiquitinating enzyme USP2a."
"14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."
"ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage."
"The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."
"MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer."
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