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Mdfi (GeneName), MyoD family inhibitor (ProteinName), MDFI_MOUSE.
Product Name:

Mouse Mdfi/ MyoD family inhibitor ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Myogenic repressor I-mf

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse MyoD family inhibitor
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Mdfi ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
The C-terminus interacts with AXIN1 and LEF1 (PubMed:12192039). Interacts with CCNT2.


Function:
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.


Subcellular Location:
Nucleus Cytoplasm


This product has not yet been referenced specifically in any publications.

[1].
"Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription."

[2].
"The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17."

[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[4].
"The DNA sequence and analysis of human chromosome 6."

[5].
"DNA methylation of CMTM3, SSTR2, and MDFI genes in colorectal cancer."

[6].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."

[7].
"Pooled-matrix protein interaction screens using Barcode Fusion Genetics."

[8].
"An inter-species protein-protein interaction network across vast evolutionary distance."

[9].
"Widespread macromolecular interaction perturbations in human genetic disorders."

[10].
"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
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