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MDFIC (基因名), MyoD family inhibitor domain-containing protein (蛋白名), MDFIC_HUMAN.
产品名称:

Human MDFIC/ MyoD family inhibitor domain-containing protein ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

I-mfa domain-containing protein, hIC

检测方法:
ELISA
特异性:
Natural and recombinant human MyoD family inhibitor domain-containing protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MDFIC ELISA Kit
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Human MDFIC ELISA Kit
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产品说明书
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通用注释


亚单元:
Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with ZIC2 (By similarity). The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1 (PubMed:12192039, PubMed:12944466, PubMed:16260749, Ref.6). Interacts with CCNT2 (PubMed:17289077).


功能:
Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.


亚细胞位置:
Isoform 2 Cytoplasm Weak expression in the nucleus.


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