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MDFIC (GeneName), MyoD family inhibitor domain-containing protein (ProteinName), MDFIC_HUMAN.
Product Name:

Human MDFIC/ MyoD family inhibitor domain-containing protein ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

I-mfa domain-containing protein, hIC

Detection Method:
ELISA
Specificity:
Natural and recombinant human MyoD family inhibitor domain-containing protein
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MDFIC ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with ZIC2 (By similarity). The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1 (PubMed:12192039, PubMed:12944466, PubMed:16260749, Ref.6). Interacts with CCNT2 (PubMed:17289077).


Function:
Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.


Subcellular Location:
Isoform 2 Cytoplasm Weak expression in the nucleus.


This product has not yet been referenced specifically in any publications.

[1].
"Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression."

[2].
"Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription."

[3].
"Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity."

[4].
"The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription."

[5].
"I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways."

[6].
"Sequence requirement for the nucleolar localization of human I-mfa domain-containing protein (HIC p40)."

[7].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[8].
"The 3'UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells."

[9].
"The complex regulation of HIC (Human I-mfa domain containing protein) expression."

[10].
"Expression profile and differential regulation of the Human I-mfa domain-Containing protein (HIC) gene in immune cells."
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