Mad2l2 (基因名), Mitotic spindle assembly checkpoint protein MAD2B (蛋白名), MD2L2_RAT.
Rat Mad2l2/ Mitotic spindle assembly checkpoint protein MAD2B ELISA Kit
Mitotic arrest deficient 2-like protein 2, MAD2-like protein 2
Natural and recombinant rat Mitotic spindle assembly checkpoint protein MAD2B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homooligomer. Interacts with REV1. Interacts with ADAM9. Interacts with CHAMP1. Interacts with REV3L. Interacts with FZR1 (in complex with the anaphase promoting complex APC). May interact with CDC20. Interacts with RAN. Interacts with ELK1; the interaction is direct and recruits MAD2L2 to ELK1-specific promoters. May interact with the JNK kinases MAPK8 and/or MAPK9 to stimulate ELK1 phosphorylation and transcriptional activity upon DNA damage. Interacts with TCF7L2; prevents its binding to promoters and negatively modulates its transcriptional activity. Interacts with YY1AP1. Interacts with PRCC; the interaction is direct. Interacts with POGZ.
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Nucleus Cytoplasm Cytoskeleton Spindle Cytoplasm
MTTLTRQDLN | FGQVVADVLS | EFLEVAVHLI | LYVREVYPVG | IFQKRKKYNV |
PVQMSCHPEL | NQYIQDTLHC | VKPLLEKNDV | EKVVVVILDK | EHRPVEKFVF |
EITQPPLLSI | NSDSLLSHVE | QLLRAFILKI | SVCDAVLDHN | PPGCTFTVLV |
HTREAATRNM | EKIQVIKDFP | WILADEQDVH | MHDPRLIPLK | TMTSDILKMQ |
LYVEERAHKN | S
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