MAD2L2 (GeneName), Mitotic spindle assembly checkpoint protein MAD2B (ProteinName), MD2L2_HUMAN.
Human MAD2L2/ Mitotic spindle assembly checkpoint protein MAD2B ELISA Kit
Mitotic arrest deficient 2-like protein 2, MAD2-like protein 2, REV7 homolog, hREV7, MAD2B, REV7
Natural and recombinant human Mitotic spindle assembly checkpoint protein MAD2B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homooligomer (Probable). Interacts with REV1. Interacts with ADAM9. Interacts with CHAMP1. Interacts with FZR1 (in complex with the anaphase promoting complex APC). Interacts with CDC20; PubMed:11459825 could not detect the interaction. Interacts with RAN. Interacts with ELK1; the interaction is direct and recruits MAD2L2 to ELK1-specific promoters. May interact with the JNK kinases MAPK8 and/or MAPK9 to stimulate ELK1 phosphorylation and transcriptional activity upon DNA damage. Interacts with TCF7L2; prevents its binding to promoters and negatively modulates its transcriptional activity. Interacts with YY1AP1. Interacts with S.flexneri protein ipaB; prevents the interaction of MAD2L2 with FZR1 and CDC20 resulting in an activation of the anaphase-promoting complex APC and a cell cycle arrest. Interacts with PRCC; the interaction is direct. Interacts with POGZ. Heterodimer with REV3L. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta (PubMed:24449906).
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Nucleus Cytoplasm Cytoskeleton Spindle Cytoplasm
MTTLTRQDLN | FGQVVADVLC | EFLEVAVHLI | LYVREVYPVG | IFQKRKKYNV |
PVQMSCHPEL | NQYIQDTLHC | VKPLLEKNDV | EKVVVVILDK | EHRPVEKFVF |
EITQPPLLSI | SSDSLLSHVE | QLLRAFILKI | SVCDAVLDHN | PPGCTFTVLV |
HTREAATRNM | EKIQVIKDFP | WILADEQDVH | MHDPRLIPLK | TMTSDILKMQ |
LYVEERAHKG | S
This product has not yet been referenced specifically in any publications.
"Characterization of MAD2B and other mitotic spindle checkpoint genes."
"Biallelic inactivation of REV7 is associated with Fanconi anemia."
"Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1."
"Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk."
"Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2."
"Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7."
"Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas."
"A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2."
"DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity."
"FAM35A associates with REV7 and modulates DNA?damage responses of normal and BRCA1-defective cells."
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