027-59234612(+86)
EIAab
Home  >  ELISA Kit  >  Chicken MAD2L2 ELISA Kit
MAD2L2 (GeneName), Mitotic spindle assembly checkpoint protein MAD2B (ProteinName), MD2L2_CHICK.
Product Name:

Chicken MAD2L2/ Mitotic spindle assembly checkpoint protein MAD2B ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mitotic arrest deficient 2-like protein 2, MAD2-like protein 2, REV7

Detection Method:
ELISA
Specificity:
Natural and recombinant chicken Mitotic spindle assembly checkpoint protein MAD2B
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
Chicken MAD2L2 ELISA Kit
Size & Price: Sign In.
×
Chicken MAD2L2 ELISA Kit
Email *
Message *
Please Sign In.
Product Datasheets


General Annotation


Sub Unit:
Homooligomer. Interacts with REV1. Interacts with FZR1 (in complex with the anaphase promoting complex APC). May interact with CDC20 (By similarity). Heterodimer with REV3L. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.


Function:
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Through transcriptional regulation may play a role in epithelial-mesenchymal transdifferentiation.


Subcellular Location:
Nucleus Cytoplasm Cytoskeleton Spindle Cytoplasm


This product has not yet been referenced specifically in any publications.

[1].
"Characterization of MAD2B and other mitotic spindle checkpoint genes."

[2].
"Biallelic inactivation of REV7 is associated with Fanconi anemia."

[3].
"Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1."

[4].
"Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk."

[5].
"Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2."

[6].
"Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7."

[7].
"Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas."

[8].
"A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2."

[9].
"DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity."

[10].
"FAM35A associates with REV7 and modulates DNA?damage responses of normal and BRCA1-defective cells."
Close
Sample Data
Close
Sample Data
Close
Sample Data
My Cart close
Attention close
History close
Clear All
Comparison close
User
My Cart
Attention
History
Comparison
Top
Message
close_message
Product Name *
Email *
Message: *
Inform
new Message
Size Quantity Price ($) Subtotal 1 ($)
Subtotal 2: $
triangle
Size Quantity Price ($)
Do you want to be our agent and get a lower discount?
Please contact us:
Tel:027-59234612(+86)
Fax:027-59759960(+86)
Email:sales@eiaab.com