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首页  >  酶联免疫试剂盒  >  Chicken MAD2L2 ELISA Kit
MAD2L2 (基因名), Mitotic spindle assembly checkpoint protein MAD2B (蛋白名), MD2L2_CHICK.
产品名称:

Chicken MAD2L2/ Mitotic spindle assembly checkpoint protein MAD2B ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mitotic arrest deficient 2-like protein 2, MAD2-like protein 2, REV7

检测方法:
ELISA
特异性:
Natural and recombinant chicken Mitotic spindle assembly checkpoint protein MAD2B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Chicken MAD2L2 ELISA Kit
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Chicken MAD2L2 ELISA Kit
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产品说明书


通用注释


亚单元:
Homooligomer. Interacts with REV1. Interacts with FZR1 (in complex with the anaphase promoting complex APC). May interact with CDC20 (By similarity). Heterodimer with REV3L. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.


功能:
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Through transcriptional regulation may play a role in epithelial-mesenchymal transdifferentiation.


亚细胞位置:
Nucleus Cytoplasm Cytoskeleton Spindle Cytoplasm


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