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首页  >  酶联免疫试剂盒  >  Human MAD2L1 ELISA Kit
MAD2L1 (基因名), Mitotic spindle assembly checkpoint protein MAD2A (蛋白名), MD2L1_HUMAN.
产品名称:

Human MAD2L1/ Mitotic spindle assembly checkpoint protein MAD2A ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2

检测方法:
ELISA
特异性:
Natural and recombinant human Mitotic spindle assembly checkpoint protein MAD2A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Human MAD2L1 ELISA Kit
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Human MAD2L1 ELISA Kit
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产品说明书


通用注释


亚单元:
Monomer and homodimer. Heterotetramer with MAD1L1. Formation of a heterotetrameric core complex containing two molecules each of MAD1L1 and of MAD2L1 promotes binding of another molecule of MAD2L1 to each MAD2L1, resulting in a heterohexamer. Interacts with CDC20, MAD2L1BP and with ADAM17/TACE. Dimeric MAD2L1 in the closed conformation interacts with CDC20. Monomeric MAD2L1 in the open conformation does not interact with CDC20. CDC20 competes with MAD1L1 for MAD2L1 binding. Interacts with TPR. Binds to UBD during mitosis. Interacts with isoform 1 and isoform 2 of NEK2. Interacts with HSF1; this interaction occurs in mitosis (PubMed:18794143).


功能:
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.


亚细胞位置:
Nucleus Chromosome Centromere Kinetochore Cytoplasm Cytoplasm Cytoskeleton Spindle pole Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD.


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