MAD2L1BP (GeneName), MAD2L1-binding protein (ProteinName), MD2BP_HUMAN.
Human MAD2L1BP/ MAD2L1-binding protein ELISA Kit
Caught by MAD2 protein, CMT2, KIAA0110, p31(comet)
Natural and recombinant human MAD2L1-binding protein
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MAD2L1.
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
Nucleus Cytoplasm Cytoskeleton Spindle During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
MAAPEAEVLS | SAAVPDLEWY | EKSEETHASQ | IELLETSSTQ | EPLNASEAFC |
PRDCMVPVVF | PGPVSQEGC | CQFTCELLKH | IMYQRQQLPL | PYEQLKHFYR |
KPSPQAEEML | KKKPRATTEV | S SRKCQQAL | AELESVLSHL | EDFFARTLVP |
RVLILLGGNA | LSPKEFYELD | LSLLAPYSVD | QS LSTAACL | RRLFRAIFMA |
DAFSELQAPP | LMGTVVMAQG | HRNCGEDWFR | PKLNYRVPSR | GHK LTVTLS |
CGRPSIRTTA | WEDYIWFQAP | VTFKGFRE
This product has not yet been referenced specifically in any publications.
"Identification of a MAD2-binding protein, CMT2, and its role in mitosis."
"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
"p31comet blocks Mad2 activation through structural mimicry."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"The DNA sequence and analysis of human chromosome 6."
"MAD2-p31comet axis deficiency reduces cell proliferation, migration and sensitivity of microtubule-interfering agents in glioma."
"Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex."
"The inositol 5-phosphatase INPP5K participates in the fine control of ER organization."
"Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison."
"Architecture of the human interactome defines protein communities and disease networks."
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