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MAD1L1 (GeneName), Mitotic spindle assembly checkpoint protein MAD1 (ProteinName), MD1L1_HUMAN.
Product Name:

Human MAD1L1/ Mitotic spindle assembly checkpoint protein MAD1 ELISA Kit

Cat.#:

E5695h

Brand:
EIAab®
Regulatory Status:
Alternative:

Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, Tax-binding protein 181, MAD1, TXBP181

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.078ng/mL
Specificity:
Natural and recombinant human Mitotic spindle assembly checkpoint protein MAD1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Cancer
Human MAD1L1 ELISA Kit
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Human MAD1L1 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex and the viral Tax protein. Interacts with NEK2. Interacts with TPR; the interactions occurs in a microtubule-independent manner.


Function:
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.


Subcellular Location:
Nucleus Chromosome Centromere Kinetochore Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytoskeleton Spindle From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore.


This product has not yet been referenced specifically in any publications.

[1].
"Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1."

[2].
"NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling."

[3].
"Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint."

[4].
"Phosphorylation of human MAD1 by the BUB1 kinase in vitro."

[5].
"Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5."
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