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Med12l (GeneName), Mediator of RNA polymerase II transcription subunit 12-like protein (ProteinName), MD12L_MOUSE.
Product Name:

Mouse Med12l/ Mediator of RNA polymerase II transcription subunit 12-like protein ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mediator complex subunit 12-like protein, Kiaa3007

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Mediator of RNA polymerase II transcription subunit 12-like protein
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Med12l ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
May be a component of the Mediator complex, which is known to be composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.


Function:
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3."

[2].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[3].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
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