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MCUR1 (GeneName), Mitochondrial calcium uniporter regulator 1 (ProteinName), MCUR1_HUMAN.
Product Name:

Human MCUR1/ Mitochondrial calcium uniporter regulator 1 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

MCU regulator 1, Coiled-coil domain-containing protein 90A, mitochondrial, C6orf79, CCDC90A

Detection Method:
ELISA
Specificity:
Natural and recombinant human Mitochondrial calcium uniporter regulator 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MCUR1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts (via coiled coil regions) with MCU; the interaction is direct (PubMed:23178883, PubMed:26341627, PubMed:27184846, PubMed:26976564). Interacts with SMDT1/EMRE; the interaction is direct (PubMed:27184846). Interacts with PPIF (PubMed:26976564).


Function:
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).


Subcellular Location:
Mitochondrion inner membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism."

[2].
"Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition."

[3].
"MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics."

[4].
"CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter."

[5].
"MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter."

[6].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[7].
"Architecture of the human interactome defines protein communities and disease networks."

[8].
"Analysis of the structure and function of EMRE in a yeast expression system."

[9].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[10].
"N-terminome analysis of the human mitochondrial proteome."
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