MCUB (GeneName), Calcium uniporter regulatory subunit MCUb, mitochondrial (ProteinName), MCUB_HUMAN.
Human MCUB/ Calcium uniporter regulatory subunit MCUb, mitochondrial ELISA Kit
MCUb, Coiled-coil domain-containing protein 109B, CCDC109B
Natural and recombinant human Calcium uniporter regulatory subunit MCUb, mitochondrial
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Heterooligomer with MCU; this reduces MCU channel activity. Homooligomer (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Mitochondrion inner membrane Multi-pass membrane protein
MLQRGLWPWR | TRLLPTPGTW | RPARPWPLPP | PPQVLRVKLC | GNVKYYQSHH |
YSTVVPPDEI | TVIYRHGLPL | VTLTLPSRKE | RCQFVVKPML | STVGSFLQDL |
QNEDKGIKTA | AIFTADGNMI | SASTLMDILL | MNDFKLVINK | IAYDVQCPKR |
EKPSNEHTAE | MEHMKSLVHR | LFTILHLEES | QKKREHHLLE | KIDHLKEQLQ |
PLEQVKAGIE | AHSEAKTSGL | LWAGLALLSI | QGGALAWLTW | WVYSWDIMEP |
VTYFITFANS | MVFFAYFIVT | RQDYTYSAVK | SRQFLQFFHK | KSKQQHFDVQ |
QYNKLKEDLA | KAKESLKQAR | HSLCLQMQVE | ELNEKN
This product has not yet been referenced specifically in any publications.
"The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit."
"EMRE is an essential component of the mitochondrial calcium uniporter complex."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"Coiled-coil domain containing 109B is a HIF1α-regulated gene critical for progression of human gliomas."
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
"Seven new loci associated with age-related macular degeneration."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
"A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts."
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