Mcts1 (GeneName), Malignant T-cell-amplified sequence 1 (ProteinName), MCTS1_MOUSE.
Mouse Mcts1/ Malignant T-cell-amplified sequence 1 ELISA Kit
MCT-1, Multiple copies T-cell malignancies 1
Natural and recombinant mouse Malignant T-cell-amplified sequence 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Malignant T-cell-amplified sequence 1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Interacts (via PUA domain) with DENR.
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3.
MFKKFDEKEN | VSNCIQLKTS | VIKGIKNQLL | EQFPGIEPWL | NQIMPKKDPV |
KIVRCHEHIE | ILTVNGELLF | FRQREGPFYP | TLRLLHKYPF | ILPHQQVDKG |
AIKFVLSGAN | IMCPGLTSPG | AKLYPAAVDT | IVAIMAEGKQ | HALCVGVMKM |
SAEDIEKVNK | GIGIENIHYL | NDGLWHMKTY | K
This product has not yet been referenced specifically in any publications.
"MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles."
"A novel candidate oncogene, MCT-1, is involved in cell cycle progression."
"DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth."
"Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies."
"Expression and stabilization of the MCT-1 protein by DNA damaging agents."
"Architecture of the human interactome defines protein communities and disease networks."
"Structural and Functional Insights into Human Re-initiation Complexes."
"Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1."
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