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首页  >  酶联免疫试剂盒  >  Mouse Adam15 ELISA Kit
Adam15 (基因名), Disintegrin and metalloproteinase domain-containing protein 15 (蛋白名), ADA15_MOUSE.
产品名称:

Mouse Adam15/ Disintegrin and metalloproteinase domain-containing protein 15 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

AD56, Metalloprotease RGD disintegrin protein, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, Metargidin, MDC-15, ADAM 15, Mdc15

检测方法:
ELISA
特异性:
Natural and recombinant mouse Disintegrin and metalloproteinase domain-containing protein 15
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Adam15 ELISA Kit
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Mouse Adam15 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts specifically with Src family protein-tyrosine kinases (PTKs) (By similarity). Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1. Interacts with SH3PXD2A (By similarity). Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC.


功能:
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration (By similarity). Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Interactions with egg membrane could be mediated via binding between the disintegrin-like domain to one or more integrin receptors on the egg.


亚细胞位置:
Endomembrane system Single-pass type I membrane protein Cell junction Adherens junction Cell projection Cilium Flagellum Cytoplasmic vesicle Secretory vesicle Acrosome The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.


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