Adam10 (基因名), Disintegrin and metalloproteinase domain-containing protein 10 (蛋白名), ADA10_RAT.
Rat Adam10/ Disintegrin and metalloproteinase domain-containing protein 10 ELISA Kit
Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c, ADAM 10, Madm
Natural and recombinant rat Disintegrin and metalloproteinase domain-containing protein 10
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with EPHA2, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells. Interacts with NGF in a divalent cation-dependent manner. Interacts with TSPAN14; the interaction promotes ADAM10 maturation and cell surface expression. Interacts with TSPAN5, TSPAN10, TSPAN15, TSPAN17 and TSPAN33; these interacations regulate ADAM10 substrate specificity.
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
Cell membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
GPELLRKKRT | TLPERNTCQL | YIQTDHLFFK | SYGTREAVIA | QISSHVKAID |
AIYQTTDFSG | IRNISFMVKR | IRINTTSDEK | DPTNPFRFPN | IGVEKFLELN |
SEQNHDDYCL | AYVFTDRDFD | DGVLGLAWVG | APSGSSGGIC | EKSKLYSDGK |
KKSLNTGIIT | VQNYGSHVPP | KVSHITFAHE | VGHNFGSPHD | SGTECTPGES |
KNLGQKENGN | YIMYARATSG | DKLNNNKFSL | CSIRNISQVL | EKKRNNCFVE |
SGQPICGNGM | VEQGEECDCG | YSDQCKDECC | FDANQPEGKK | CKLKPGKQCS |
PSQGPCCTAQ | CAFKSKSEKC | RDDSDCAKEG | ICNGFTALCP | ASDPKPNFTD |
CNRHTQVCIN | GQCAGSICEK | YDLEECTCAS | SDGKDDKELC | HVCCMKKMAP |
STCASTGSLQ | WNKQFTGRTI | TLQPGSPCND | FRGYCDVFMR | CRLVDADGPL |
ARLKKAIFSP | QLYENIAEWI | VAHWWAVLLM | GIALIMLMAG | FIKICSVHTP |
SSNPKLPPPK | PLPGTLKRRR | PPQPIQQPQR | QRPRESYQMG | HMRR
评论数 : 0
规格 数量 单价 (￥) 小计 1 (￥)
小计 2: ￥
规格 数量 单价 (￥)