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首页  >  酶联免疫试剂盒  >  Pig ADAM10 ELISA Kit
ADAM10 (基因名), Disintegrin and metalloproteinase domain-containing protein 10 (蛋白名), ADA10_PIG.
产品名称:

Pig ADAM10/ Disintegrin and metalloproteinase domain-containing protein 10 ELISA Kit
解整合素样金属蛋白酶10

货号:

E0766p

商标:
EIAab®
监管等级:
别名:

Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c, ADAM 10

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant pig Disintegrin and metalloproteinase domain-containing protein 10
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Pig ADAM10 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

94-104%

105-115%

107-117%

103-112%

EDTA plasma(n=5)

106-116%

82-91%

106-115%

100-109%

heparin plasma(n=5)

103-113%

 

89-99%

106-116%

97-106%

 

通用注释


亚单元:
Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with EPHA2, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells. Interacts with NGF in a divalent cation-dependent manner. Interacts with TSPAN14; the interaction promotes ADAM10 maturation and cell surface expression. Interacts with TSPAN5, TSPAN10, TSPAN15, TSPAN17 and TSPAN33; these interacations regulate the ADAM10 substrate cleaving.


功能:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.


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