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ASPA (GeneName), Aspartoacylase (ProteinName), ACY2_BOVIN.
Product Name:

Bovine ASPA/ Aspartoacylase ELISA Kit

Cat.#:

E2260b

Brand:
EIAab®
Regulatory Status:
Alternative:

Aminoacylase-2, ACY-2, ACY2

Detection Method:
ELISA
Assay Type:
Sandwich
Specificity:
Natural and recombinant bovine Aspartoacylase
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Neurosciences
Bovine ASPA ELISA Kit
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Bovine ASPA ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Homodimer.


Function:
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter.


Subcellular Location:
Cytoplasm Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Structure of aspartoacylase, the brain enzyme impaired in Canavan disease."

[2].
"Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease."

[3].
"Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue."

[4].
"Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease."

[5].
"Purification and preliminary characterization of brain aspartoacylase."

[6].
"Two novel aspartoacylase gene (ASPA) missense mutations specific to Norwegian and Swedish patients with Canavan disease."

[7].
"Identification and characterization of novel mutations of the aspartoacylase gene in non-Jewish patients with Canavan disease."

[8].
"Identification and expression of eight novel mutations among non-Jewish patients with Canavan disease."

[9].
"The molecular basis of canavan (aspartoacylase deficiency) disease in European non-Jewish patients."

[10].
"Canavan disease: mutations among Jewish and non-Jewish patients."
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