Acvr1 (GeneName), Activin receptor type-1 (ProteinName), ACVR1_MOUSE.
Mouse Acvr1/ Activin receptor type-1 ELISA Kit
Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, TSK-7L, Acvrlk2, Tgfb1
Natural and recombinant mouse Activin receptor type-1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with FKBP1A. Interacts with FCHO1.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.
Membrane Single-pass type I membrane protein
MVDGVMILPV | LMMMAFPSPS | VEDEKPKVNQ | KLYMCVCEGL | SCGNEDHCEG |
QQCFSSLSIN | DGFHVYQKGC | FQVYEQGKMT | CKTPPSPGQA | VECCQGDWCN |
RNITAQLPTK | GKSFPGTQNF | HLEVGLIILS | VVFAVCLLAC | ILGVALRKFK |
RRNQERLNPR | DVEYGTIEGL | ITTNVGDSTL | AELLDHSCTS | GSGSGLPFLV |
QRTVARQITL | LECVGKGRYG | EVWRGSWQGE | NVAVKIFSSR | DEKSWFRETE |
LYNTVMLRHE | NILGFIASDM | TSRHSSTQLW | LITHYHEMGS | LYDYLQLTTL |
DTVSCLRIVL | SIASGLAHLH | IEIFGTQGKS | AIAHRDLKSK | NILVKKNGQC |
CIADLGLAVM | HSQSTNQLDV | GNNPRVGTKR | YMAPEVLDET | IQVDCFDSYK |
RVDIWAFGLV | LWEVARRMVS | NGIVEDYKPP | FYDVVPNDPS | FEDMRKVVCV |
DQQRPNIPNR | WFSDPTLTSL | AKLMKECWYQ | NPSARLTALR | IKKTLTKIDN |
This product has not yet been referenced specifically in any publications.
"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
"Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1."
"Variants in the ACVR1 gene are associated with AMH levels in women with polycystic ovary syndrome."
"A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor."
"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."
"Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium."
"Mutational screening of ACVR1 gene in Brazilian fibrodysplasia ossificans progressiva patients."
"Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients."
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