ACVR1 (GeneName), Activin receptor type-1 (ProteinName), ACVR1_BOVIN.
Product Name:
Bovine ACVR1/ Activin receptor type-1 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, ACVRLK2
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Activin receptor type-1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Interacts with FKBP1A. Interacts with FCHO1.
Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May also bind activin.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Database link
This product has not yet been referenced specifically in any publications.
[1].
"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
[2].
"Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1."
[3].
"Variants in the ACVR1 gene are associated with AMH levels in women with polycystic ovary syndrome."
[4].
"A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor."
[5].
"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."
[6].
"Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage."
[7].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
[8].
"Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium."
[9].
"Mutational screening of ACVR1 gene in Brazilian fibrodysplasia ossificans progressiva patients."
[10].
"Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients."
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