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Acvrl1 (GeneName), Serine/threonine-protein kinase receptor R3 (ProteinName), ACVL1_RAT.

Product Name:

Rat Acvrl1/ Serine/threonine-protein kinase receptor R3 ELISA Kit

Cat.#:

E1901r

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

SKR3, TGF-B superfamily receptor type I, TSR-I, Acvrlk1

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

0.156-10ng/mL

Sensitivity:

0.088ng/mL

Specificity:

Natural and recombinant rat Serine/threonine-protein kinase receptor R3

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

Cell Biology

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Rat Acvrl1 ELISA Kit

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Product Datasheets

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

N/A

Function:

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Database link

UniGene:

Rn.10631

SMR:

P80203

STRING:

10116.ENSRNOP00000008673

KEGG:

rno:25237

Pfam:

PF07714

Uniprot:

P80203

Related Product

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Mouse Acvrl1 ELISA Kit

Human ACVRL1 CLIA Kit

Mouse Acvrl1 CLIA Kit

Human ACVRL1 Protein

Sequence length:

504

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504:

KVIH

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype."

(PMID: 16752392)

[2].

"Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2."

(PMID: 8640225)

[3].

"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."

(PMID: 8397373)

[4].

"Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."

(PMID: 22718755)

[5].

"Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation."

(PMID: 20056902)

[6].

"Mutation analysis of "Endoglin" and "Activin receptor-like kinase" genes in German patients with hereditary hemorrhagic telangiectasia and the value of rapid genotyping using an allele-specific PCR-technique."

(PMID: 19508727)

[7].

"Detection of a significant association between mutations in the ACVRL1 gene and hepatic involvement in German patients with hereditary haemorrhagic telangiectasia."

(PMID: 18498373)

[8].

"Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease."

(PMID: 18187665)

[9].

"Hereditary hemorrhagic telangiectasia: clinical features in ENG and ALK1 mutation carriers."

(PMID: 17388964)

[10].

"Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia."

(PMID: 16525724)

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