ACVR1C (GeneName), Activin receptor type-1C (ProteinName), ACV1C_HUMAN.
Product Name:
Human ACVR1C/ Activin receptor type-1C ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ALK7
Detection Method:
ELISA
Specificity:
Natural and recombinant human Activin receptor type-1C
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Binds the type 2 receptor protein ACVR2A.
Function:
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Database link
UniGene:
SMR:
STRING:
KEGG:
MIM:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7."
[2].
"Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta."
[3].
"cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)."
[4].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
[5].
"ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease."
[6].
"Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7."
[7].
"Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells."
[8].
"Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines."
[9].
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
[10].
"Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells."
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