ACVR1C (GeneName), Activin receptor type-1C (ProteinName), ACV1C_HUMAN.
Human ACVR1C/ Activin receptor type-1C ELISA Kit
Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ALK7
Natural and recombinant human Activin receptor type-1C
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Binds the type 2 receptor protein ACVR2A.
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Membrane Single-pass type I membrane protein
MTRALCSALR | QALLLLAAAA | ELSPGLKCVC | LLCDSSNFTC | QTEGACWASV |
MLTNGKEQVI | KSCVSLPELN | AQVFCHSSNN | VTKTECCFTD | FCNNITLHLP |
TASPNAPKLG | PMELAIIITV | PVCLLSIAAM | LTVWACQGRQ | CSYRKKKRPN |
VEEPLSECNL | VNAGKTLKDL | IYDVTASGSG | SGLPLLVQRT | IARTIVLQEI |
VGKGRFGEVW | HGRWCGEDVA | VKIFSSRDER | SWFREAEIYQ | TVMLRHENIL |
GFIAADNKDN | GTWTQLWLVS | EYHEQGSLYD | YLNRNIVTVA | GMIKLALSIA |
SGLAHLHMEI | VGTQGKPAIA | HRDIKSKNIL | VKKCETCAIA | DLGLAVKHDS |
ILNTIDIPQN | PKVGTKRYMA | PEMLDDTMNV | NIFESFKRAD | IYSVGLVYWE |
IARRCSVGGI | VEEYQLPYYD | MVPSDPSIEE | MRKVVCDQKF | RPSIPNQWQS |
CEALRVMGRI | MRECWYANGA | ARLTALRIKK | TISQLCVKED | CKA
This product has not yet been referenced specifically in any publications.
"Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7."
"Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta."
"cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease."
"Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7."
"Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells."
"Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines."
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
"Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells."
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