Acvr1b (GeneName), Activin receptor type-1B (ProteinName), ACV1B_RAT.
Rat Acvr1b/ Activin receptor type-1B ELISA Kit
Activin receptor type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2, Acvrlk4, Alk4
Natural and recombinant rat Activin receptor type-1B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Interacts with TDP2 (By similarity). Interacts with AIP1, FKBP1A, IGSF1, TDGF1, SMAD2, SMAD3 and SMAD7.
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Cell membrane Single-pass type I membrane protein
MAESAGASSF | FPLVVLLLAG | SGGSGPRGIQ | ALLCACTSCL | QTNYTCETDG |
ACMVSIFNLD | GMEHHVRTCI | PKVELVPAGK | PFYCLSSEDL | RNTHCCYIDF |
CNKIDLRVPS | GHLKEPEHPS | MWGPVELVGI | IAGPVFLLFL | IIIIVFLVIN |
YHQRVYHNRQ | RLDMEDPSCE | MCLSKDKTLQ | DLVYDLSTSG | SGSGLPLFVQ |
RTVARTIVLQ | EIIGKGRFGE | VWRGRWRGGD | VAVKIFSSRE | ERSWFREAEI |
YQTVMLRHEN | ILGFIAADNK | DNGTWTQLWL | VSDYHEHGSL | FDYLNRYTVT |
IEGMIKLALS | AASGLAHLHM | EIVGTQGKPG | IAHRDLKSKN | ILVKKNGMCA |
IADLGLAVRH | DAVTDTIDIA | PNQRVGTKRY | MAPEVLDETI | NMKHFDSFKC |
ADIYALGLVY | WEIARRCNSG | GVHEEYQLPY | YDLVPSDPSI | EEMRKVVCDQ |
KLRPNVPNWW | QSYEALRVMG | KMMRECWYAN | GAARLTALRI | KKTLSQLSVQ |
This product has not yet been referenced specifically in any publications.
"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
"Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas."
"FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor."
"Identification of a functional binding site for activin on the type I receptor ALK4."
"Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells."
"Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells."
"Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)."
"Activation of signalling by the activin receptor complex."
"Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin."
"Activation of the activin A-ALK-Smad pathway in systemic sclerosis."
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